Regulation of Th17 cells by P. UF1 against systemic Listeria monocytogenes infection

Gut Microbes. 2018;9(3):279-287. doi: 10.1080/19490976.2017.1417731. Epub 2018 Feb 8.


Regulation of Th17 and Th1 cell responses against intracellular pathogens, including Listeria monocytogenes (L. m), is critical to limit inflammation-induced tissue damage. We recently demonstrated the ability of P. UF1 bacterium derived from the intestinal bacterial commensals of preterm infants fed human breast milk to significantly mitigate pathogen-induced inflammation limiting colonic tissue damage. Here we further elucidated the potential of P. UF1 to also regulate innate and T cells, particularly Th17 and Th1 cells, against systemic L. m infection. Data demonstrate that P. UF1 not only robustly regulated protective Th17 and Th1 cells, but also sustained regulatory T cells (Treg cells) resulting in accelerated L. m clearance. Together, regulation of pathogenic inflammation by a novel probiotic bacterium such as P. UF1 may illuminate a new strategy to specifically control Th17-Th1 cells via IL-10+ Treg cells to limit systemic tissue damage induced by intracellular pathogens, including L. m.

Keywords: Listeria monocytogenes; P. UF1 bacterium; SIGNR1; Th1 cells; Th17 cells; mucosal immunity; regulatory T cells.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Animals
  • Antibiosis*
  • Bacterial Load
  • Bacterial Proteins / genetics
  • Bacterial Proteins / immunology
  • Feces / microbiology
  • Gastrointestinal Microbiome / physiology
  • Listeria monocytogenes / immunology*
  • Listeriosis / immunology
  • Listeriosis / microbiology
  • Listeriosis / prevention & control*
  • Liver / microbiology
  • Mice
  • Mice, Inbred C57BL
  • Mutation
  • Probiotics / administration & dosage*
  • Propionibacterium / genetics
  • Propionibacterium / immunology*
  • T-Lymphocyte Subsets / immunology*
  • T-Lymphocytes, Regulatory / immunology
  • Th1 Cells
  • Th17 Cells


  • Bacterial Proteins