Abstract
Increasing usage of next generation sequencing (NGS) technology will illuminate the extent of RNA modifications, which may affect various pathophysiological conditions. Here, we will highlight one such category of RNA modification called “RNA editing”, which can be detected from RNA sequencing (RNA-seq) data by simply modifying the data analysis pipeline using bioinformatics methods.
Keywords:
RNA editing; adenosine; gene expression; inosine; mice.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Adenosine / metabolism
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Adenosine Deaminase / physiology
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Animals
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Atherosclerosis / enzymology
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Cardiovascular Diseases / genetics*
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Cardiovascular Diseases / metabolism
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Cathepsins / genetics
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Cyanosis
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Heart / physiology
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Heart Defects, Congenital / genetics
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Heart Defects, Congenital / metabolism
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Inosine / metabolism
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Mediator Complex / metabolism
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RNA Editing*
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Regeneration
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Salamandridae
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Sequence Analysis, RNA
Substances
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MED13 protein, human
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Mediator Complex
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Inosine
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Cathepsins
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cathepsin S
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Adenosine Deaminase
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Adenosine