When Acetylcholine Unlocks Feedback Inhibition in Cortex

Quentin Chevy; Adam Kepecs

doi:10.1016/j.neuron.2018.01.042

When Acetylcholine Unlocks Feedback Inhibition in Cortex

Neuron. 2018 Feb 7;97(3):481-484. doi: 10.1016/j.neuron.2018.01.042.

Authors

Quentin Chevy¹, Adam Kepecs²

Affiliations

¹ Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA.
² Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA. Electronic address: kepecs@cshl.edu.

PMID: 29420929
DOI: 10.1016/j.neuron.2018.01.042

Abstract

Acetylcholine promotes cognitive function through the regulation of cortical circuits. In this issue of Neuron, Urban-Ciecko et al. (2018) demonstrate how this neuromodulator can rapidly boost synapses from pyramidal to somatostatin neurons, unlocking a new computational ability in the cortical microcircuitry.

Publication types

Research Support, N.I.H., Extramural
Comment

MeSH terms

Acetylcholine*
Neocortex*
Nicotine
Pyramidal Cells
Synapses

Substances

Nicotine
Acetylcholine