Flavonoids from Mirabilis himalaica

Xue Li; Mingxia Yin; Xuedong Yang; Guang Yang; Xian Gao

doi:10.1016/j.fitote.2018.02.005

Flavonoids from Mirabilis himalaica

Fitoterapia. 2018 Jun:127:89-95. doi: 10.1016/j.fitote.2018.02.005. Epub 2018 Feb 5.

Authors

Xue Li¹, Mingxia Yin¹, Xuedong Yang², Guang Yang³, Xian Gao⁴

Affiliations

¹ School of Pharmaceutical Science and Technology, Tianjin University, Tianjin 300072, PR China.
² School of Pharmaceutical Science and Technology, Tianjin University, Tianjin 300072, PR China. Electronic address: yangxd@tju.edu.cn.
³ State Key Laboratory of Medicinal Chemical Biology and College of Pharmacy, Nankai University, Tianjin 300071, PR China.
⁴ State Key Laboratory of Medicinal Chemical Biology and College of Pharmacy, Nankai University, Tianjin 300071, PR China; Tianjin Key Laboratory of Molecular Drug Research, Tianjin International Joint Academy of Biomedicine, Tianjin 300457, PR China. Electronic address: 212015109@mail.nankai.edu.cn.

PMID: 29421242
DOI: 10.1016/j.fitote.2018.02.005

Abstract

Six previously undescribed flavonoids, 2S-5-methoxy-6-methyl-7,2'-dihydroxyflavanone, 5,7,2'-trihydroxy-6-methylflavone, 5,7,6'-trihydroxy-6-methylcoumaronochromone, 2,4',6'-trihydroxy-2'-methoxy-3'-methylchalcone, 6R,11-dimethoxy-9-hydroxyrotenoid, and 6R,11-dimethoxy-9-hydroxy-10-methylrotenoid, along with eight known flavonoids, including 2S-5-methoxy-6-methyl-7,4'-dihydroxyflavanone, not previously reported as a natural product, and seven rotenoids, boeravinone A, B, D, P, F, coccineone B, and mirabijalone E, were isolated from the ethyl acetate soluble fraction of Mirabilis himalaica roots. Their structures were established by the extensive spectroscopic analysis, including HRESIMS, UV, NMR and ECD. All compounds were evaluated for their cytotoxic activities against three human cancer cell lines: A375 (melanoma), A549 (lung), and PLC (hepatoma).

Keywords: Cytotoxicity; Flavonoids; Mirabilis himalaica; Nyctaginaceae; Rotenoids.

MeSH terms

Cell Line, Tumor
Flavonoids / isolation & purification*
Humans
Mirabilis / chemistry*
Molecular Structure
Plant Roots / chemistry*

Substances

Flavonoids