[Effect of fragments E and D on the plasmin hydrolysis of the fibrin clot]

Biokhimiia. 1986 Jun;51(6):967-9.
[Article in Russian]

Abstract

It was found that fragments E (Mr = 45 000), DH (Mr = 95 000) and DL (Mr = 82 000) decrease the rate of plasmin hydrolysis of fibrin that is not cross-linked with factor XIII; the most effective inhibitor is fragment DL. The Kd values for the interactions of fragments E, DH and DL with plasmin are equal to 0.15, 0.4 and 0.04 microM, respectively.

Publication types

  • English Abstract

MeSH terms

  • Blood Coagulation Tests
  • Fibrin Fibrinogen Degradation Products / analysis*
  • Fibrin Fibrinogen Degradation Products / pharmacology*
  • Fibrinolysin / analysis*
  • Humans
  • Hydrolysis
  • In Vitro Techniques

Substances

  • Fibrin Fibrinogen Degradation Products
  • fibrinogen D fragment
  • fibrinogen fragment E
  • Fibrinolysin