AMPK Wars: the VMH Strikes Back, Return of the PVH

Trends Endocrinol Metab. 2018 Mar;29(3):135-137. doi: 10.1016/j.tem.2018.01.004.


Hypothalamic AMP-activated protein kinase (AMPK) is an important modulator of whole-body energy homeostasis, particularly within the ventromedial nucleus, where it regulates energy expenditure, glucose, and lipid metabolism. A recent paper in Cell Reports has demonstrated that AMPK in the paraventricular nucleus of the hypothalamus modulates dietary preference for carbohydrate over fat.

Keywords: AMPK; carbohydrate; feeding; paraventricular nucleus of the hypothalamus.

Publication types

  • Research Support, Non-U.S. Gov't
  • Comment

MeSH terms

  • AMP-Activated Protein Kinases*
  • Diet
  • Energy Metabolism
  • Glucose
  • Hypothalamus*


  • AMP-Activated Protein Kinases
  • Glucose