Comparative evaluation of different gradient diffusion tests for detection of azole resistance in Aspergillus fumigatus

Diagn Microbiol Infect Dis. 2018 May;91(1):52-54. doi: 10.1016/j.diagmicrobio.2018.01.003. Epub 2018 Jan 9.

Abstract

Gradient diffusion assays Etest and MIC Test Strip for itraconazole, posaconazole and voriconazole as well as isavuconazole (MIC Test Strip) were evaluated for Aspergillus fumigatus against EUCAST broth microdilution. Both assays demonstrated generally good performance; however, posaconazole MIC Test Strip showed low agreement with broth microdilution due to MIC overestimation.

Keywords: Aspergillus fumigatus; Azole antifungals; EUCAST broth microdilution; Etest; Gradient diffusion assays; MIC Test Strip.

Publication types

  • Comparative Study
  • Evaluation Study

MeSH terms

  • Antifungal Agents / pharmacology*
  • Aspergillosis / microbiology*
  • Aspergillus fumigatus / drug effects*
  • Aspergillus fumigatus / isolation & purification
  • Azoles / pharmacology*
  • Disk Diffusion Antimicrobial Tests
  • Drug Resistance, Fungal*
  • Itraconazole / pharmacology
  • Microbial Sensitivity Tests / methods*
  • Nitriles / pharmacology
  • Pyridines / pharmacology
  • Reproducibility of Results
  • Triazoles / pharmacology
  • Voriconazole / pharmacology

Substances

  • Antifungal Agents
  • Azoles
  • Nitriles
  • Pyridines
  • Triazoles
  • Itraconazole
  • isavuconazole
  • posaconazole
  • Voriconazole