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. 2018 Jan 30:9:8.
doi: 10.1186/s13229-018-0194-8. eCollection 2018.

The bidirectional association between sleep problems and autism spectrum disorder: a population-based cohort study

Maria E Verhoeff  1   2 , Laura M E Blanken  1   2 , Desana Kocevska  1   2 , Viara R Mileva-Seitz  1 , Vincent W V Jaddoe  1   3   4 , Tonya White  2   5 , Frank Verhulst  2 , Maartje P C M Luijk  2   6 , Henning Tiemeier  2   4   7
Affiliations

The bidirectional association between sleep problems and autism spectrum disorder: a population-based cohort study

Maria E Verhoeff et al. Mol Autism. .

Abstract

Background: Sleep difficulties are prevalent in children with autism spectrum disorder (ASD). The temporal nature of the association between sleep problems and ASD is unclear because longitudinal studies are lacking. Our aim is to clarify whether sleep problems precede and worsen autistic traits and ASD or occur as a consequence of the disorder.

Methods: Repeated sleep measures were available at 1.5, 3, 6, and 9 years of age in 5151 children participating in the Generation R Study, a large prospective birth cohort in the Netherlands. Autistic traits were determined with the Pervasive Developmental Problems score (PDP) of the Child Behavior Checklist (CBCL) at 1.5 and 3 years and the Social Responsiveness Scale (SRS) at 6 years. This cohort included 81 children diagnosed with ASD.

Results: Sleep problems in early childhood were prospectively associated with a higher SRS score, but not when correcting for baseline PDP score. By contrast, a higher SRS score and an ASD diagnosis were associated with more sleep problems at later ages, even when adjusting for baseline sleep problems. Likewise, a trajectory of increasing sleep problems was associated with ASD.

Conclusions: Sleep problems and ASD are not bidirectionally associated. Sleep problems do not precede and worsen autistic behavior but rather co-occur with autistic traits in early childhood. Over time, children with ASD have an increase in sleep problems, whereas typically developing children have a decrease in sleep problems. Our findings suggest that sleep problems are part of the construct ASD.

Keywords: Autism; Bidirectional; Birth cohort; General population; Sleep problems.

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Conflict of interest statement

The Medical Ethical Committee of the Erasmus Medical Center Rotterdam approved the study. We obtained written informed consent from all participants and their parents.Not applicable.The funders had no role in the study design, data collection, analysis, interpretation of the data, or writing of the report. F.C.V. is the contributing editor of the Achenbach System of Empirically Based Assessment, from which he receives remuneration. All other authors declare that they have no competing interests.Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Figures

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Fig. 1
Population and measurements overview
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