Persistence of memory B-cell and T-cell responses to the quadrivalent HPV vaccine in HIV-infected children

AIDS. 2018 Apr 24;32(7):851-860. doi: 10.1097/QAD.0000000000001773.


Objective: To determine the magnitude and persistence of quadrivalent human papillomavirus (HPV)16 and HPV18 B-cell and T-cell memory after three or four doses of quadrivalent HPV vaccine (QHPV) in HIV-infected children.

Methods: Seventy-four HIV-infected children immunized with four doses and 23 with three doses of QHPV had HPV16 and HPV18 IgG B-cell and IFNγ and IL2 T-cell ELISPOT performed at 2, 3.5 and 4-5 years after the last dose.

Results: HPV16 and HPV18 T-cell responses were similar in both treatment groups, with higher responses to HPV16 vs. HPV18. These HPV T-cell responses correlated with HIV disease characteristics at the study visits. Global T-cell function declined over time as measured by nonspecific mitogenic stimulation. B-cell memory was similar across treatment groups and HPV genotypes. There was a decline in HPV-specific B-cell memory over time that reached statistical significance for HPV16 in the four-dose group.

Conclusion: B-cell and T-cell memory did not significantly differ after either three or four doses of QHPV in HIV-infected children. The clinical consequences of decreasing global T-cell function and HPV B-cell memory over time in HIV-infected children requires further investigation.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • B-Lymphocytes / immunology*
  • Cell Proliferation
  • Child
  • Enzyme-Linked Immunospot Assay
  • Female
  • HIV Infections / complications*
  • Human papillomavirus 16 / immunology*
  • Human papillomavirus 18 / immunology*
  • Humans
  • Immunologic Memory*
  • Interferon-gamma / metabolism
  • Interleukin-2 / metabolism
  • Longitudinal Studies
  • Male
  • Papillomavirus Infections / prevention & control
  • Papillomavirus Vaccines / administration & dosage
  • Papillomavirus Vaccines / immunology*
  • T-Lymphocytes / immunology*


  • IL2 protein, human
  • Interleukin-2
  • Papillomavirus Vaccines
  • Interferon-gamma