Splicing regulation by long noncoding RNAs

Nucleic Acids Res. 2018 Mar 16;46(5):2169-2184. doi: 10.1093/nar/gky095.

Abstract

Massive high-throughput sequencing techniques allowed the identification of thousands of noncoding RNAs (ncRNAs) and a plethora of different mRNA processing events occurring in higher organisms. Long ncRNAs can act directly as long transcripts or can be processed into active small si/miRNAs. They can modulate mRNA cleavage, translational repression or the epigenetic landscape of their target genes. Recently, certain long ncRNAs have been shown to play a crucial role in the regulation of alternative splicing in response to several stimuli or during disease. In this review, we focus on recent discoveries linking gene regulation by alternative splicing and its modulation by long and small ncRNAs.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Alternative Splicing*
  • Animals
  • Gene Expression Regulation*
  • Humans
  • MicroRNAs / metabolism*
  • Models, Genetic
  • Neoplasms / genetics
  • Neoplasms / pathology
  • RNA, Long Noncoding / genetics*
  • RNA, Messenger / genetics*
  • RNA, Small Untranslated / genetics*

Substances

  • MicroRNAs
  • RNA, Long Noncoding
  • RNA, Messenger
  • RNA, Small Untranslated