Regulatory identification of BPA as an endocrine disruptor: Context and methodology

Mol Cell Endocrinol. 2018 Nov 5;475:4-9. doi: 10.1016/j.mce.2018.02.001. Epub 2018 Feb 6.


BPA is one of the most investigated substances for its endocrine disruptor (ED) properties and it is at the same time in the center of many ED-related controversies. The analysis on how BPA fits to the regulatory identification as an ED is a challenge in terms of methodology. It is also a great opportunity to test the regulatory framework with a uniquely data-rich substance and learn valuable lessons for future cases. From this extensive database, it was considered important to engage in a detailed analysis so as to provide specific and strong evidences of ED while reflecting accurately the complexity of the response as well the multiplicity of adverse effects. An appropriate delineation of the scope of the analysis was therefore critical. Four effects namely, alterations of estrous cyclicity, mammary gland development, brain development and memory function, and metabolism, were considered to provide solid evidence of ED-mediated effects of BPA.

Keywords: Bisphenol A; ED; Endocrine disruption; REACh; SVHC; Substance of very high concern.

Publication types

  • Review

MeSH terms

  • Animals
  • Benzhydryl Compounds / chemistry
  • Benzhydryl Compounds / toxicity*
  • Endocrine Disruptors / chemistry
  • Endocrine Disruptors / toxicity*
  • Humans
  • Phenols / chemistry
  • Phenols / toxicity*
  • Social Control, Formal*


  • Benzhydryl Compounds
  • Endocrine Disruptors
  • Phenols
  • bisphenol A