Allicin ameliorates cognitive impairment in APP/PS1 mice via Suppressing oxidative stress by Blocking JNK Signaling Pathways

Tissue Cell. 2018 Feb;50:89-95. doi: 10.1016/j.tice.2017.11.002. Epub 2017 Dec 2.

Abstract

In middle and old age, Alzheimer's disease (AD) is a progressive neurodegenerative disorder of brain. As an increasingly aging population, AD represents a huge burden for the patients' family and the country. However, current therapeutical strategies have shown limited effectiveness. Allicin, which is the main composition of garlic, was reported to prevent the learning and memory impairment of AD mouse model. As the mechanism is not clear, in this study, we used the APP (amyloid precursor protein)/PS1 (presenilin 1) double transgenic mice, which express human mutant APP and PS1, to determine the protective effect of allicin on neurons. AD involves a broad range of clinical, cellular, and biochemical manifestations. This has led to many views of AD, e.g. the amyloid, presenilin, oxidative stress, and mitochondrial dysfunction. We confirmed that allicin improves the cognitive function of APP/PS1 double transgenic mice by reducing the expression levels of Aβ, oxidative stress, and improving mitochondrial dysfunction. Application of behavioral, morphological and molecular biology, and other means were conducted to investigate the effect of allicin, which provide an experimental basis for the reliable application of allicin in the treatment of neurodegenerative diseases.

Keywords: APP (amyloid precursor protein)/PS1 (presenilin 1) mouse; Allicin; Alzheimer's disease.

MeSH terms

  • Alzheimer Disease / drug therapy*
  • Alzheimer Disease / genetics
  • Alzheimer Disease / pathology
  • Amyloid beta-Protein Precursor / genetics*
  • Animals
  • Brain / drug effects
  • Brain / pathology
  • Cognitive Dysfunction / drug therapy*
  • Cognitive Dysfunction / genetics
  • Cognitive Dysfunction / pathology
  • Disease Models, Animal
  • Humans
  • Mice
  • Mice, Transgenic
  • Neurons / drug effects
  • Neurons / pathology
  • Oxidative Stress / drug effects
  • Presenilin-1 / genetics*
  • Signal Transduction / drug effects
  • Sulfinic Acids / administration & dosage*

Substances

  • Amyloid beta-Protein Precursor
  • Presenilin-1
  • Sulfinic Acids
  • presenilin 1, mouse
  • allicin