Vitamin D supplementation attenuates the behavioral scores of neuropathic pain in rats

Nutr Neurosci. 2019 Oct;22(10):700-705. doi: 10.1080/1028415X.2018.1435485. Epub 2018 Feb 12.


Objective(s): Neuropathic pain due to lesion or dysfunction of the peripheral or central nervous system is often refractory to the conventional analgesics. Currently, there is no proven treatment to prevent or cure neuropathic pain. A recent surge of new data suggests the potential effects of vitamin D in the medical community. This study was designed to determine whether acute or chronic vitamin D administration was effective in alleviating symptoms of neuropathic pain in a rat model of neuropathic pain. Materials and Methods: Neuropathic pain was induced by chronic constriction injury (CCI) of the sciatic nerve in the rats that resulted in thermal hyperalgesia, mechanical, and cold allodynia. Results: Acute vitamin D injections (250, 500, and 1000 unit/kg i.p.) on the 7th, 14th, and 21st postoperative days could not attenuate mechanical and cold allodynia as well as heat hyperalgesia compared to CCI group. But when vitamin D (1000 unit/kg i.p.) administration was started on the first day after surgery and given daily until the 21st day, cold allodynia and heat hyperalgesia considerably were attenuated. However, no differences in paw withdrawal thresholds were observed. Conclusion: These results indicate that chronic vitamin D administrations can attenuate the behavioral scores of neuropathic pain in rats.

Keywords: Hyperalgesia; Neuropathic pain; Rat; Vitamin D.

MeSH terms

  • Animals
  • Behavior, Animal / drug effects
  • Disease Models, Animal
  • Hyperalgesia / complications
  • Hyperalgesia / drug therapy
  • Male
  • Neuralgia / complications
  • Neuralgia / drug therapy*
  • Pain Threshold / drug effects
  • Rats, Sprague-Dawley
  • Sciatic Nerve / injuries
  • Vitamin D / administration & dosage*


  • Vitamin D