Gadolinium-Free Contrast Agents for Magnetic Resonance Imaging of the Central Nervous System

Eric M Gale; Peter Caravan

doi:10.1021/acschemneuro.8b00044

Gadolinium-Free Contrast Agents for Magnetic Resonance Imaging of the Central Nervous System

ACS Chem Neurosci. 2018 Mar 21;9(3):395-397. doi: 10.1021/acschemneuro.8b00044. Epub 2018 Feb 12.

Authors

Eric M Gale¹, Peter Caravan¹

Affiliation

¹ The Athinoula A. Martinos Center for Biomedical Imaging, The Institute for Innovation in Imaging, Department of Radiology , Massachusetts General Hospital, Harvard Medical School , 149 Thirteenth Street, Suite 2301 , Charlestown , Massachusetts 02129 , United States.

Abstract

We discuss how the recent revelation that gadolinium (Gd) from commercially available MRI contrast agents is irreversibly and cumulatively deposited in the central nervous system is driving innovation toward Gd-free contrast agents for neuroradiology.

Keywords: GBCA; Gadolinium; central nervous system; magnetic resonance imaging.

Publication types

Research Support, N.I.H., Extramural

MeSH terms

Central Nervous System / pathology*
Contrast Media*
Gadolinium DTPA
Gadolinium*
Humans
Image Processing, Computer-Assisted / methods
Magnetic Resonance Imaging* / methods

Substances

Contrast Media
Gadolinium
Gadolinium DTPA

Abstract

Publication types

MeSH terms

Substances

Grants and funding