Female androgenic alopecia. The 3 alpha,17 beta-androstanediol glucuronide/sex hormone binding globulin ratio as a possible marker for female pattern baldness

Arch Dermatol. 1986 Sep;122(9):1011-5. doi: 10.1001/archderm.122.9.1011.

Abstract

Twenty-five women fulfilling the criteria for female alopecia, of either the male pattern baldness type or female pattern baldness type, were evaluated for hormone markers to delineate the clinical baldness patterns. Women with a marked increase in the 3 alpha,17 beta-androstanediol glucuronide/sex hormone binding globulin ratio and low serum sex hormone binding globulin were noted to have female pattern baldness. This pattern of baldness may represent hair loss from the influence of minimal androgen excess on genetically sensitive hair bulbs in the absence of other signs of maximal androgen excess, including hirsutism, acne, or virilism.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Alopecia / blood*
  • Androgens / metabolism*
  • Androstane-3,17-diol / analogs & derivatives
  • Androstane-3,17-diol / blood*
  • Androstanols / blood*
  • Dehydroepiandrosterone / analogs & derivatives
  • Dehydroepiandrosterone / blood
  • Dehydroepiandrosterone Sulfate
  • Dihydrotestosterone / blood
  • Female
  • Humans
  • Middle Aged
  • Sex Hormone-Binding Globulin / analysis*
  • Testosterone / blood

Substances

  • Androgens
  • Androstanols
  • Sex Hormone-Binding Globulin
  • Dihydrotestosterone
  • Androstane-3,17-diol
  • androstane-3,17-diol glucuronide
  • Testosterone
  • Dehydroepiandrosterone
  • Dehydroepiandrosterone Sulfate