Toxic effects of fluoride on organisms

Life Sci. 2018 Apr 1;198:18-24. doi: 10.1016/j.lfs.2018.02.001. Epub 2018 Feb 9.


Accumulation of excess fluoride in the environment poses serious health risks to plants, animals, and humans. This endangers human health, affects organism growth and development, and negatively impacts the food chain, thereby affecting ecological balance. In recent years, numerous studies focused on the molecular mechanisms associated with fluoride toxicity. These studies have demonstrated that fluoride can induce oxidative stress, regulate intracellular redox homeostasis, and lead to mitochondrial damage, endoplasmic reticulum stress and alter gene expression. This paper reviews the present research on the potential adverse effects of overdose fluoride on various organisms and aims to improve our understanding of fluoride toxicity.

Keywords: Environment; Fluoride; Organisms; Toxicity.

Publication types

  • Review

MeSH terms

  • Animals
  • Apoptosis
  • Ecology
  • Endoplasmic Reticulum Stress
  • Environmental Pollutants / toxicity*
  • Fluorides / chemistry
  • Fluorides / toxicity*
  • Gases
  • Homeostasis / drug effects*
  • Humans
  • Insecta
  • Membrane Potential, Mitochondrial / drug effects
  • Mitochondria / metabolism
  • Mitochondria / pathology
  • Oxidation-Reduction
  • Oxidative Stress / drug effects*
  • Permeability
  • Phosphates / toxicity
  • Proteomics


  • Environmental Pollutants
  • Gases
  • Phosphates
  • fluorophosphate
  • Fluorides