Acid folic and pregnancy: A mandatory supplementation

Ann Endocrinol (Paris). 2018 Apr;79(2):91-94. doi: 10.1016/j.ando.2017.10.001. Epub 2018 Feb 9.


Neural tube defects (NTD) occur in 0.5 to 2 per 1000 pregnancies with various handicaps for the affected child. It is now well established that folic acid deficiency (absolute or relative) is a predisposing factor to this type of malformation. Several randomized controlled trials showed that high-dose folic acid (4mg) is an essential factor for prevention of neural tube defects recurrence and significantly prevents the first occurrence of neural tube defects with a lower dose (0.4mg). Other etiologies can favor the occurrence of NTD such as MTHFR polymorphism, some antiepileptic therapies, obesity and pregestational mellitus diabetes. Necessity of a preconception folic acid supplementation or at least folate nutritional status evaluation should be known for all of us including patients and public.

Keywords: Acide folique; Anomalies du tube neural; Folates; Folic acid; Grossesse; Neural tube defects; Pregnancy.

Publication types

  • Review

MeSH terms

  • Adult
  • Dietary Supplements*
  • Female
  • Folic Acid / therapeutic use*
  • Folic Acid Deficiency / complications
  • Folic Acid Deficiency / drug therapy*
  • Humans
  • Infant, Newborn
  • Neural Tube Defects / etiology
  • Neural Tube Defects / prevention & control
  • Preconception Care
  • Pregnancy
  • Prenatal Care / standards*


  • Folic Acid