Water-based versus alcohol-based benzoyl peroxide preparations in the treatment of acne vulgaris

Dermatologica. 1986;172(5):263-7. doi: 10.1159/000249352.

Abstract

Forty-eight patients with acne vulgaris in the face were treated with a water-based (Basiron) and an alcohol-based (Panoxyl) 5% benzoyl peroxide preparation. A randomized double-blind, contralateral study was used. No difference in clinical effect was found. Treatment for 8 weeks resulted in at least 50% reduction in the number of closed comedones, papules and pustules in over 80% of the patients. In more than 70% of the patients, the reduction exceeded 75%. The water-based Basiron caused significantly less skin irritation than the alcohol-based preparation of Panoxyl.

Publication types

  • Clinical Trial
  • Comparative Study
  • Randomized Controlled Trial

MeSH terms

  • Acne Vulgaris / drug therapy*
  • Administration, Topical
  • Adolescent
  • Adult
  • Benzoyl Peroxide / administration & dosage*
  • Benzoyl Peroxide / adverse effects
  • Clinical Trials as Topic
  • Dermatitis, Contact / etiology
  • Double-Blind Method
  • Erythema / chemically induced
  • Ethanol
  • Female
  • Gels
  • Humans
  • Male
  • Peroxides / administration & dosage*
  • Random Allocation
  • Water

Substances

  • Gels
  • Peroxides
  • Water
  • Ethanol
  • Benzoyl Peroxide