Systematic review of the efficacy of statins for the treatment of Alzheimer's disease

Clin Med (Lond). 2018 Feb;18(1):54-61. doi: 10.7861/clinmedicine.18-1-54.


Alzheimer's disease (AD) is the most common type of dementia. Recent studies have assessed the possibility of using statins as treatment for AD. However, their efficacy is not clear. In this study, we collected the most relevant information about the efficacy of statins for the treatment of AD. We conducted a systematic literature search using MEDLINE, EMBASE and The Cochrane Library. We included clinical trials, meta-analyses and systematic reviews that analysed the efficacy of statins in AD. We also extracted the characteristics and efficacy results of the studies selected. Of the 304 articles identified, 13 complied with the inclusion criteria. The scientific quality of studies was high and their results indicated that there were no significant differences in the main efficacy variables between statins and placebo treatment for AD. Therefore, according to the available scientific evidence, statins have not shown an improvement in cognition and do not appear to offer significant benefits to patients with AD.

Keywords: Alzheimer's disease; efficacy; statins; systematic review.

Publication types

  • Systematic Review

MeSH terms

  • Alzheimer Disease / drug therapy
  • Alzheimer Disease / psychology
  • Cognition / drug effects
  • Humans
  • Hydroxymethylglutaryl-CoA Reductase Inhibitors / pharmacology*
  • Treatment Outcome


  • Hydroxymethylglutaryl-CoA Reductase Inhibitors