Successful Combination Therapy of Liposomal Amphotericin B and Caspofungin for Disseminated Fusariosis in a Pediatric Patient With Acute Lymphoblastic Leukemia

Pediatr Infect Dis J. 2018 Oct;37(10):e251-e253. doi: 10.1097/INF.0000000000001941.

Abstract

Disseminated fusariosis is a fatal infection in immunocompromised hosts. However, the optimal antifungal treatment for disseminated fusariosis has not yet been established. We report a case of disseminated fusariosis after chemotherapy for acute lymphoblastic leukemia, presenting with multiple skin, lung and kidney lesions and cerebrospinal fluid invasion. The combination therapy of liposomal amphotericin B and caspofungin resolved disseminated fusariosis successfully.

Publication types

  • Case Reports

MeSH terms

  • Amphotericin B / administration & dosage
  • Amphotericin B / therapeutic use*
  • Antifungal Agents / therapeutic use*
  • Caspofungin / administration & dosage
  • Caspofungin / therapeutic use*
  • Child
  • Drug Therapy
  • Drug Therapy, Combination
  • Female
  • Fever / etiology
  • Fusariosis / diagnosis
  • Fusariosis / drug therapy*
  • Humans
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma / complications*
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma / drug therapy

Substances

  • Antifungal Agents
  • liposomal amphotericin B
  • Amphotericin B
  • Caspofungin