Alteration in the serum concentrations of FGF19, FGFR4 and βKlotho in patients with thyroid cancer

Cytokine. 2018 May:105:32-36. doi: 10.1016/j.cyto.2018.02.013. Epub 2018 Feb 10.


Introduction: βKlotho (βKL) is known to act as co-receptor for fibroblast growth factor receptor 4 (FGFR4) which is the main cognate receptor for fibroblast growth factor 19 (FGF19). Dysregulation of this FGF19/FGFR4/βKL signaling axis has been implicated in the pathogenesis of several cancers. However, its role in the pathogenesis of thyroid cancer has not been determined.

Materials and methods: The aim of this study was to assess FGF19, FGFR4 and βKL concentrations in a group of 36 patients with papillary thyroid cancer (PTC), 11 patients with follicular thyroid cancer (FTC), 9 patients with anaplastic thyroid cancer (ATC) and a group of 19 subjects with multinodular nontoxic goiter (MNG). The control group consisted of 20 healthy volunteers. Serum FGF19, FGFR4 and βKL concentrations were measured using specific ELISA methods.

Results: Significantly lower concentrations of βKL and higher concentrations of FGF19 were found in patients with PTC, FTC and ATC as compared with MNG group and controls. An elevation of FGFR4 serum concentration was observed in all thyroid cancer groups in comparison to MNG group and controls; however, in FTC group it was statistically insignificant. A positive correlation was found between βKL and FGFR4 concentrations in PTC patients. The levels of βKL, FGF19 and FGFR4 did not differ significantly between MNG group and healthy controls.

Conclusions: Our results indicate that a disrupted FGF19/FGFR4/βKL signaling pathway may play a role in the development of thyroid cancers. However, further studies are needed to elucidate the molecular mechanism of the neoplastic transition of thyroid epithelial cells.

Keywords: FGF19; FGFR4; Serum concentration; Thyroid cancer; βKlotho.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Female
  • Fibroblast Growth Factors / blood*
  • Humans
  • Klotho Proteins
  • Male
  • Membrane Proteins / blood*
  • Middle Aged
  • Neoplasm Staging
  • Receptor, Fibroblast Growth Factor, Type 4 / blood*
  • Thyroid Neoplasms / blood*
  • Thyroid Neoplasms / diagnosis
  • Thyroid Neoplasms / pathology


  • FGF19 protein, human
  • KLB protein, human
  • Membrane Proteins
  • Fibroblast Growth Factors
  • FGFR4 protein, human
  • Receptor, Fibroblast Growth Factor, Type 4
  • Klotho Proteins