Defusing inflammasomes

J Exp Med. 2018 Mar 5;215(3):723-724. doi: 10.1084/jem.20180241. Epub 2018 Feb 12.

Abstract

In this issue of JEM, Boucher et al. (https://doi.org/10.1084/jem.20172222) report isolation of active caspase-1 from macrophages after inflammasome activation. Surprisingly, they find that caspase-1 is quickly inactivated upon autoproteolytic processing.

Publication types

  • Comment

MeSH terms

  • Caspase 1
  • Inflammasomes*
  • Interleukin-1beta
  • Macrophages*

Substances

  • Inflammasomes
  • Interleukin-1beta
  • Caspase 1