Synthetic biology: Reframing cell therapy for cancer

Taylor B Dolberg; Patrick S Donahue; Joshua N Leonard

doi:10.1038/nchembio.2573

Synthetic biology: Reframing cell therapy for cancer

Nat Chem Biol. 2018 Feb 14;14(3):204-205. doi: 10.1038/nchembio.2573.

Authors

Taylor B Dolberg¹, Patrick S Donahue^{1

2}, Joshua N Leonard¹

Affiliations

¹ Department of Chemical and Biological Engineering and the Center for Synthetic Biology, Northwestern University, Evanston, Illinois, USA.
² Interdisciplinary Biological Sciences Program, Northwestern University, Evanston, Illinois, USA and the Medical Scientist Training Program, Northwestern University, Chicago, Illinois, USA.

Abstract

Technologies for engineering immune cells to recognize features on cancer cells are transforming oncology. Synthetic biologists now expand this approach by conferring therapeutic functions to nonimmune cells, and by programming cells to sense and respond to a new class of physiological cues.

Publication types

Comment

MeSH terms

Cell- and Tissue-Based Therapy
Receptors, Antigen, T-Cell*
Synthetic Biology*
T-Lymphocytes

Substances

Receptors, Antigen, T-Cell

Abstract

Publication types

MeSH terms

Substances

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