Association of admission serum levels of vitamin D, calcium, Phosphate, magnesium and parathormone with clinical outcomes in neurosurgical ICU patients

Sci Rep. 2018 Feb 14;8(1):2965. doi: 10.1038/s41598-018-21177-4.


To evaluate the association of admission serum levels of 25(OH)D, parathormone and the related electrolytes with severity of illness and clinical outcomes in neurosurgical critically ill patients, serum levels of 25(OH)D, parathormone, calcium, magnesium, and phosphate, along with APACHE II score were measured for 210 patients upon admission. Mean serum 25(OH)D was 21.1 ± 7.4 ng/mL. 25(OH)D deficiency (less than 20 ng/dL) and elevated serum parathormone level were found in 47.6% and 38% of patients respectively. Hypocalcaemia, hypophosphatemia, hypomagnesaemia and hypermagnesaemia were found in 29.5%, %63.8, 41.9% and 27.6% of patients respectively. The APACHE II score was significantly correlated with serum levels of 25(OH)D, parathormone, calcium, and phosphate. Multivariate regression analysis adjusted by other risk factors showed that among all clinical outcomes, admission hypovitaminosis D was associated with longer duration of ICU stay and a high admission of parathormone was associated with in ICU mortality. We concluded that disorders of admission serum levels of 25(OH)D, parathormone, calcium, magnesium, and phosphate are related to the presence of multiple causal factors such as severity of disease and are not independently associated with clinical outcomes. Most often they are normalize spontaneously with resolution of the disease process.

MeSH terms

  • Brain Neoplasms / diagnosis*
  • Brain Neoplasms / mortality
  • Brain Neoplasms / surgery
  • Calcium / blood
  • Critical Illness
  • Diagnostic Tests, Routine
  • Female
  • Humans
  • Intensive Care Units
  • Length of Stay / statistics & numerical data
  • Magnesium / blood
  • Male
  • Neurosurgical Procedures*
  • Parathyroid Hormone / blood*
  • Phosphates / blood
  • Prognosis
  • Prospective Studies
  • Survival Analysis
  • Treatment Outcome
  • Vitamin D / blood*


  • Parathyroid Hormone
  • Phosphates
  • Vitamin D
  • Magnesium
  • Calcium