Improvement in Neuropathy Specific Quality of Life in Patients with Diabetes after Vitamin D Supplementation

J Diabetes Res. 2017;2017:7928083. doi: 10.1155/2017/7928083. Epub 2017 Dec 28.

Abstract

Objective: To assess the effect of vitamin D supplementation on neuropathy specific quality of life (NeuroQoL) in patients with painful diabetic neuropathy.

Methods: This prospective, open label study was conducted between June 2012 and April 2013. Patients with symptomatic diabetic neuropathy were given a single dose of 600,000 IU intramuscular vitamin D, and NeuroQol was assessed at baseline and at five follow-up visits every 4 weeks.

Results: Of 143 participants, 41.3% were vitamin D deficient (vitamin D < 20 ng/ml). Treatment with vitamin D resulted in a significant increase in 25(OH)D (P < 0.0001) and a significant improvement in the NeuroQoL subscale score for emotional distress (P = 0.04), with no significant change in the other NeuroQoL domains of painful symptoms and paresthesia, loss of temperature and touch sensation, unsteadiness, limitation in daily activities, and interpersonal problems. There was a significant reduction in patient perception about foot problems on QoL of "quite a lot" (P < 0.05) and "very much" (P < 0.0001) with a significant reduction in the baseline response of having a "poor" QoL from 5.2% to 0.7% (P < 0.0001) and an increase in the response of an "excellent QoL" from 1.5% to 7.4% (P < 0.0001).

Conclusion: Vitamin D is effective in improving quality of life in patients with painful diabetic neuropathy.

Publication types

  • Clinical Trial

MeSH terms

  • 25-Hydroxyvitamin D 2 / blood
  • Adult
  • Asymptomatic Diseases / therapy
  • Cost of Illness*
  • Diabetes Mellitus, Type 1 / complications
  • Diabetes Mellitus, Type 1 / psychology
  • Diabetes Mellitus, Type 2 / complications
  • Diabetes Mellitus, Type 2 / psychology
  • Diabetic Foot / complications
  • Diabetic Foot / physiopathology
  • Diabetic Foot / prevention & control
  • Diabetic Foot / psychology
  • Diabetic Neuropathies / complications
  • Diabetic Neuropathies / physiopathology*
  • Diabetic Neuropathies / psychology
  • Female
  • Follow-Up Studies
  • Humans
  • Injections, Intramuscular
  • Male
  • Middle Aged
  • Pain / complications
  • Pain / physiopathology*
  • Pain / psychology
  • Pakistan
  • Peripheral Nervous System Diseases / complications
  • Peripheral Nervous System Diseases / physiopathology*
  • Peripheral Nervous System Diseases / psychology
  • Psychiatric Status Rating Scales
  • Quality of Life*
  • Severity of Illness Index
  • Stress, Psychological / complications
  • Stress, Psychological / etiology
  • Stress, Psychological / prevention & control*
  • Stress, Psychological / psychology
  • Vitamin D / administration & dosage
  • Vitamin D / therapeutic use*
  • Vitamin D Deficiency / blood
  • Vitamin D Deficiency / complications
  • Vitamin D Deficiency / drug therapy*
  • Vitamin D Deficiency / psychology

Substances

  • Vitamin D
  • 25-Hydroxyvitamin D 2

Supplementary concepts

  • Neuropathy, Painful