Protection against summer solar lentigo over-pigmentation with a SPF30 daily cream

Skin Res Technol. 2018 Aug;24(3):485-489. doi: 10.1111/srt.12458. Epub 2018 Feb 15.


Background/purpose: The aim of this study was to measure lentigines' pigmentation over a long period of time and evaluate if summer over-pigmentation can be avoided by the use a SPF30 day skin cream.

Methods: Seventeen healthy female volunteers aged 50 and over and presenting lentigines participated in the study from spring to summer. Throughout the study, all subjects applied a SPF30 daily skin cream to only one hand. Color measurements of the target lesions were performed with a chromameter and with a color-calibrated camera. Target lesions were also imaged with in vivo reflectance confocal microscopy (RCM). A specific procedure for re-registering the images was developed to ensure that the same papillae were measured over time.

Results: Both color measurement methods, chromametry and color-calibrated camera, showed that lentigines treated over time with the SPF30 day skin cream were significantly lighter than the non-treated lentigines. The RCM images showed a decrease in the papillary contrast for the treated lentigines.

Conclusion: This study shows that this over-pigmentation can be avoided using a SPF30 day skin cream. Moreover, we have demonstrated that very fine re-registration of the RCM images is possible and ensures a more robust analysis.

Keywords: color measurement; lentigo [MeSH]; reflectance confocal microscopy; skin [MeSH]; skin aging [MeSH]; skin cream [MeSH]; skin pigmentation [MeSH]; sun protection factor [MeSH].

Publication types

  • Randomized Controlled Trial

MeSH terms

  • Aged
  • Color*
  • Female
  • Hand Dermatoses / drug therapy
  • Hand Dermatoses / prevention & control*
  • Humans
  • Hyperpigmentation / complications
  • Hyperpigmentation / prevention & control*
  • Lentigo / complications
  • Lentigo / drug therapy*
  • Microscopy, Confocal
  • Middle Aged
  • Seasons*
  • Skin Cream / therapeutic use*
  • Sunscreening Agents / therapeutic use*


  • Sunscreening Agents