Value of 18F-FET PET in adult brainstem glioma

Abdulrahman Abdullah Albatly; Adnan Taleb Alsamarah; Abdulrahman Alhawas; Patrick Veit-Haibach; Alfred Buck; Paul Stolzmann; Irene A Burger; Spyros S Kollias; Martin W Huellner

doi:10.1016/j.clinimag.2018.01.015

Value of ¹⁸F-FET PET in adult brainstem glioma

Clin Imaging. 2018 Sep-Oct:51:68-75. doi: 10.1016/j.clinimag.2018.01.015. Epub 2018 Feb 8.

Authors

Abdulrahman Abdullah Albatly¹, Adnan Taleb Alsamarah², Abdulrahman Alhawas³, Patrick Veit-Haibach⁴, Alfred Buck⁵, Paul Stolzmann⁶, Irene A Burger⁷, Spyros S Kollias⁸, Martin W Huellner⁹

Affiliations

¹ Department of Nuclear Medicine, University Hospital Zurich/University of Zurich, Rämistrasse 100, 8091 Zurich, Switzerland; Department of Diagnostic Radiology, Prince Sultan Medical Military City, Makkah Road, Riyadh, Saudi Arabia.
² Department of Nuclear Medicine, University Hospital Zurich/University of Zurich, Rämistrasse 100, 8091 Zurich, Switzerland; Department of Neuroradiology, University Hospital Zurich/University of Zurich, Frauenklinikstrasse 10, 8091 Zurich, Switzerland; Department of Diagnostic Radiology, King Fahd University Hospital, Onizah Street, Alkhobar, Saudi Arabia.
³ Department of Nuclear Medicine, University Hospital Zurich/University of Zurich, Rämistrasse 100, 8091 Zurich, Switzerland; Department of Radiology and Medical Imaging, College of Medicine, King Saud University, Riyadh, Saudi Arabia. Electronic address: aalhawas1@ksu.edu.sa.
⁴ Department of Nuclear Medicine, University Hospital Zurich/University of Zurich, Rämistrasse 100, 8091 Zurich, Switzerland. Electronic address: patrick.veit-haibach@usz.ch.
⁵ Department of Nuclear Medicine, University Hospital Zurich/University of Zurich, Rämistrasse 100, 8091 Zurich, Switzerland. Electronic address: fred.buck@usz.ch.
⁶ Department of Nuclear Medicine, University Hospital Zurich/University of Zurich, Rämistrasse 100, 8091 Zurich, Switzerland. Electronic address: paul.stolzmann@usz.ch.
⁷ Department of Nuclear Medicine, University Hospital Zurich/University of Zurich, Rämistrasse 100, 8091 Zurich, Switzerland. Electronic address: irene.burger@usz.ch.
⁸ Department of Neuroradiology, University Hospital Zurich/University of Zurich, Frauenklinikstrasse 10, 8091 Zurich, Switzerland. Electronic address: spyros.kollias@usz.ch.
⁹ Department of Nuclear Medicine, University Hospital Zurich/University of Zurich, Rämistrasse 100, 8091 Zurich, Switzerland; Department of Neuroradiology, University Hospital Zurich/University of Zurich, Frauenklinikstrasse 10, 8091 Zurich, Switzerland. Electronic address: martin.huellner@usz.ch.

PMID: 29448122
DOI: 10.1016/j.clinimag.2018.01.015

Abstract

Purpose: To investigate ¹⁸F-fluoro-ethyl-tyrosine positron emission tomography (FET-PET) imaging characteristics of adult brainstem glioma (BSG).

Materials and methods: FET-PET imaging and progression-free survival (PFS) of 16 adult patients with BSG was analyzed (9 high-grade gliomas, 7 low-grade gliomas). SUV_max, TBR, and time activity curves of FET-PET were calculated.

Results: Progressive gliomas had higher SUV_max (3.57 ± 1.47 vs. 1.60 ± 0.51; p = 0.003) and TBR_max (3.00 ± 1.12 vs. 1.36 ± 0.33; p = 0.001) than stable gliomas. Kaplan-Meier analysis showed longer PFS of tumors with TBR_max < 2.0 compared to tumors with TBR_max > 2.0 (665 ± 32 days versus 220 ± 39 days; p < 0.001).

Conclusion: FET-PET uptake might be associated with disease progression in adult BSG.

Keywords: (18)F-FET; Adult brainstem glioma; Brain tumors; Kaplan-Meier; MR; PET; PET/CT; PET/MR; Survival; Tyrosin.

MeSH terms

Adolescent
Adult
Brain Neoplasms / diagnostic imaging*
Brain Stem / diagnostic imaging*
Disease Progression
Disease-Free Survival
Female
Glioma / diagnostic imaging*
Humans
Male
Middle Aged
Positron-Emission Tomography / methods*
Tyrosine / analogs & derivatives*
Tyrosine / pharmacology
Young Adult

Substances

(18F)fluoroethyltyrosine
Tyrosine