LaGaO3:Er3+, Yb3+ powder with different Er3+ contents (0.01~0.10 mol) was synthesized by a conventional solid-state reaction. The structure, morphology and photoluminescence properties of the as-prepared phosphors were characterized by X-ray diffraction (XRD), scanning electron microscopy (SEM), and fluorescence spectrophotometer techniques, respectively. The photoluminescence (PL) emissions based on the green emission near 522 and 544 nm were observed and the highest emission intensity occurred for the sample LaGaO3:Yb0.15, Er0.07. The green and red up-conversion emissions were observed in Er3+, Yb3+ co-doped LaGaO3 phosphors under the excitation of 980 nm laser diode.