Preliminary results of a single-arm pilot study to assess the safety and efficacy of visnadine, prenylflavonoids and bovine colostrum in postmenopausal sexually active women affected by vulvovaginal atrophy

Antonio Simone Laganà; Salvatore Giovanni Vitale; Lily Stojanovska; Irene Lambrinoudaki; Vasso Apostolopoulos; Benito Chiofalo; Laura Rizzo; Francesca Basile

doi:10.1016/j.maturitas.2017.12.015

Preliminary results of a single-arm pilot study to assess the safety and efficacy of visnadine, prenylflavonoids and bovine colostrum in postmenopausal sexually active women affected by vulvovaginal atrophy

Maturitas. 2018 Mar:109:78-80. doi: 10.1016/j.maturitas.2017.12.015. Epub 2017 Dec 24.

Authors

Antonio Simone Laganà¹, Salvatore Giovanni Vitale², Lily Stojanovska³, Irene Lambrinoudaki⁴, Vasso Apostolopoulos³, Benito Chiofalo², Laura Rizzo², Francesca Basile²

Affiliations

¹ Unit of Gynecology and Obstetrics, Department of Human Pathology in Adulthood and Childhood "G. Barresi", University of Messina, Messina, Italy. Electronic address: antlagana@unime.it.
² Unit of Gynecology and Obstetrics, Department of Human Pathology in Adulthood and Childhood "G. Barresi", University of Messina, Messina, Italy.
³ Centre for Chronic Disease, College of Health and Biomedicine, Victoria University, Melbourne, VIC, Australia.
⁴ Second Department of Obstetrics and Gynecology, National and Kapodistrian University of Athens, Greece.

PMID: 29452786
DOI: 10.1016/j.maturitas.2017.12.015

Abstract

This single-arm pilot study enrolled 47 post-menopausal women affected by vulvovaginal atrophy (VVA). The Vaginal Health Index Score (VHIS) was evaluated for all women and all completed the Female Sexual Function Index (FSFI) questionnaire at baseline (T0) and after 15 days of vaginal cream treatment with one application per day (T1). Following treatment there was a significant improvement in all VHIS parameters and total score (p < 0.0001). Similarly, there was a significant improvement on four FSFI domains (lubrication, orgasm, satisfaction and pain) and total score (p = 0.001). None of the patients reported any local or systemic side-effects during treatment.

Keywords: Bovine colostrum; Menopause; Prenylflavonoids; Sexual wellbeing; Visnadine; Vulvovaginal atrophy.

MeSH terms

Administration, Intravaginal
Animals
Atrophy / drug therapy
Cattle
Chromans / therapeutic use*
Colostrum*
Female
Flavonoids / therapeutic use*
Humans
Lubrication
Middle Aged
Orgasm
Pain / drug therapy
Personal Satisfaction
Pilot Projects
Postmenopause
Pregnancy
Surveys and Questionnaires
Treatment Outcome
Vagina / pathology*
Vulva / pathology*

Substances

Chromans
Flavonoids
visnadin