Material properties of the brain in injury-relevant conditions - Experiments and computational modeling

Abstract

Material properties of the brain have been extensively studied but remain poorly characterized. The vast variations in constitutive models and material constants are well documented. However, no study exists to translate the variations into disparities in impact-induced brain strains most relevant to brain injury. Here, we reviewed a subset of injury-relevant brain material properties either characterized in experiments or adopted in recent head injury models. To highlight how variations in measured brain material properties manifested in simulated brain strains, we selected six experiments that have provided a complete set of brain material model and constants to implement a common head injury model. Responses resulting from two extreme events representing a high-rate cadaveric head impact and a low-rate in vivo head rotation, respectively, varied substantially. We hypothesized, and further confirmed, that the time-varying shear moduli at the appropriate time scales (e.g., ~5 ms and ~40 ms corresponding to the impulse durations of the major acceleration peaks for the two impacts, respectively), rather than the initial or long-term shear moduli, were the most indicative of impact-induced brain strains. These results underscored the need to implement measured brain material properties into an actual head injury model for evaluation. They may also provide guidelines to better characterize brain material properties in future experiments and head injury models. Finally, our finding provided a practical solution to satisfy head injury model validation requirements at both ends of the impact severity spectrum. This would improve the confidence in model simulation performance across a range of time scales relevant to concussion and sub-concussion in the real-world.

Keywords: Concussion; Head injury model; Hyperelasticity; Material properties; Traumatic brain injury; Viscoelasticity.