Atrial natriuretic peptide mRNA is regulated by glucocorticoids in vivo

Biochem Biophys Res Commun. 1986 Sep 30;139(3):1047-54. doi: 10.1016/s0006-291x(86)80283-2.


In these studies glucocorticoids were found to increase the plasma levels of atrial natriuretic peptide (ANP) as well as the expression of the ANP gene in the Sprague-Dawley rat. Plasma ANP rose two-fold after 48 hrs. of exposure to dexamethasone (1 mg/day) in both intact and adrenalectomized animals. This was accompanied by a 1.5-2.0 fold increase in the levels of atrial and ventricular ANP transcripts. Deoxycorticosterone acetate (5 mg/day), administered on the same schedule, failed to increase either plasma ANP levels or cardiac ANP mRNA accumulation. These effects suggest that ANP may have a potential role as a mediator of glucocorticoid activity in the cardiovascular system and support the hypothesis that ANP is a glucocorticoid-regulated gene.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Atrial Natriuretic Factor / blood
  • Atrial Natriuretic Factor / genetics*
  • Desoxycorticosterone / pharmacology
  • Dexamethasone / pharmacology
  • Glucocorticoids / pharmacology*
  • Lamins
  • Male
  • Nucleoproteins / genetics
  • RNA, Messenger / metabolism*
  • Rats
  • Rats, Inbred Strains
  • Time Factors
  • Transcription, Genetic


  • Glucocorticoids
  • Lamins
  • Nucleoproteins
  • RNA, Messenger
  • Desoxycorticosterone
  • Dexamethasone
  • Atrial Natriuretic Factor