DDR1: A major player in renal diseases

Cell Adh Migr. 2018;12(4):299-304. doi: 10.1080/19336918.2018.1441661. Epub 2018 Feb 27.

Abstract

Discoidin Domain Receptor 1 (DDR1) belongs to a family of two non-integrin collagen receptors, DDR1 and DDR2, which display a tyrosine kinase activity. DDR1 has been widely studied in different kind of pathologies including chronic kidney diseases (CKD). The aims of this commentary are 1. to review the existing information about DDR1 expression in healthy and diseased kidney, 2. to comment the data highlighting DDR1 as a major actor in CKD, 3. to suggest areas of research which require further investigation to better characterize the signaling pathways regulating DDR1 role in CKD. The results recapitulated in this commentary emphasize the involvement of DDR1 in the pro-inflammatory and pro-fibrotic processes which drives the development of CKD. They also underline the beneficial effect of its blockade in pre-clinical models and thus, reinforce its status of interesting therapeutic target.

Keywords: Chronic Kidney Disease; Fibrotic lesions; Pro-inflammatory processes; Therapeutic target; Tyrosine kinase receptor.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Discoidin Domain Receptor 1 / antagonists & inhibitors
  • Discoidin Domain Receptor 1 / metabolism*
  • Humans
  • Kidney / metabolism
  • Kidney / pathology
  • Kidney Diseases / drug therapy
  • Kidney Diseases / metabolism*
  • Kidney Diseases / pathology

Substances

  • Discoidin Domain Receptor 1

Grant support

This work was supported by the French National Institute of Health and Medical Research and the University Paris Sorbonne.