Gastroprotective activity of polysaccharide from Hericium erinaceus against ethanol-induced gastric mucosal lesion and pylorus ligation-induced gastric ulcer, and its antioxidant activities

Carbohydr Polym. 2018 Apr 15;186:100-109. doi: 10.1016/j.carbpol.2018.01.004. Epub 2018 Jan 2.


The gastroprotective activity of Hericium erinaceus polysaccharide was investigated in rats. The antioxidant activities were also evaluated. Pre-treatment of polysaccharide could reduce ethanol-induced gastric mucosal lesion and pylorus ligation-induced gastric ulcer. The polysaccharide exhibited scavenging activities of 1, 1-diphenyl-2-picryl-hydrozyl and hydroxyl radicals, and ferrous ion-chelating ability. In the pylorus ligation-induced model, gastric secretions (volume of gastric juice, gastric acid, pepsin and mucus) of ulcer rats administrated with polysaccharide were regulated. Levels of tumor necrosis factor-α and interleukins-1β in serum, and myeloperoxidase activity of gastric tissue were reduced, while antioxidant status of gastric tissue was improved. Defensive factors (nitric oxide, prostaglandin E2, epidermal growth factor) in gastric tissue were increased. These results indicate that Hericium erinaceus polysaccharide possess gastroprotective activity, and the possible mechanisms are related to its regulations of gastric secretions, improvements of anti-inflammatory and antioxidant status, as well as increments of defensive factors releases.

Keywords: Anti-inflammatory; Antioxidant activity; Gastroprotective activity; Hericium erinaceus; Polysaccharide.

MeSH terms

  • Animals
  • Antioxidants / chemistry
  • Antioxidants / therapeutic use*
  • Dinoprostone / metabolism
  • Epidermal Growth Factor / metabolism
  • Ethanol / toxicity*
  • Gastric Mucosa / drug effects*
  • Gastric Mucosa / pathology*
  • Interleukin-1beta / metabolism
  • Nitric Oxide / metabolism
  • Polysaccharides / chemistry
  • Polysaccharides / therapeutic use*
  • Pylorus / drug effects
  • Rats
  • Stomach Ulcer / drug therapy*
  • Tumor Necrosis Factor-alpha / metabolism


  • Antioxidants
  • Interleukin-1beta
  • Polysaccharides
  • Tumor Necrosis Factor-alpha
  • Nitric Oxide
  • Ethanol
  • Epidermal Growth Factor
  • Dinoprostone