Blood perfusion in left inferior and middle frontal gyrus predicts communication skills in schizophrenia

Psychiatry Res Neuroimaging. 2018 Apr 30:274:7-10. doi: 10.1016/j.pscychresns.2018.02.002. Epub 2018 Feb 10.

Abstract

Schizophrenia is one of the most debilitating mental disorders, severely affecting patients' community functioning. Functional capacity (FC) describes the skills necessary for successful functional outcome (FO), such as financial knowledge or communication skills. We investigated whether resting-state cerebral blood flow (rCBF) measured at baseline with arterial spin labeling (ASL) would predict FC or FO at a 6-months follow-up in 27 schizophrenia patients. A negative linear association was noted between FC and rCBF in the left inferior and middle frontal gyrus, areas involved in language processing, suggesting a potential relationship between cerebral perfusion and prospective FC in schizophrenia.

Keywords: Arterial spin labeling; Functional capacity; Functional outcome; Resting-state cerebral blood flow; Schizophrenia.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Cerebrovascular Circulation / physiology*
  • Female
  • Humans
  • Male
  • Prefrontal Cortex / blood supply*
  • Schizophrenia / physiopathology*
  • Spin Labels
  • Verbal Behavior / physiology*

Substances

  • Spin Labels