Cardio-oncology: the role of advanced echocardiography in cancer patients

Expert Rev Cardiovasc Ther. 2018 Apr;16(4):249-258. doi: 10.1080/14779072.2018.1443394. Epub 2018 Feb 22.

Abstract

Cardio-oncology is a rapidly growing field aimed at improving the quality of care of cancer patients by preventing and monitoring cardiovascular complications resulting from cancer treatment. Cardiac imaging, and in particular, transthoracic echocardiography, plays an essential role in the baseline assessment and serial follow-up of cardio-oncology patients. Areas covered: This review article discusses the role of cardiac imaging with a focus on advanced echocardiography for the detection and management of cancer therapy related cardiovascular complications, in particular, left ventricular dysfunction and heart failure. Expert commentary: While traditional imaging based assessment of left ventricular ejection fraction still has its place in cardiac monitoring, more advanced echocardiographic modalities, in particular, myocardial deformation imaging with speckle tracking strain analysis, show great potential for detecting early signs of cardiotoxicity. Larger studies are needed to determine both the clinical role of strain measurement in influencing initiation of cardioprotective agents and its prognostic value in long term outcome.

Keywords: Cardiac imaging; cardio-oncology; cardiotoxicity; echocardiography; strain imaging.

Publication types

  • Review

MeSH terms

  • Antineoplastic Agents / administration & dosage
  • Antineoplastic Agents / adverse effects*
  • Cardiotoxicity* / diagnosis
  • Cardiotoxicity* / etiology
  • Early Detection of Cancer / methods
  • Echocardiography / methods*
  • Heart Diseases* / chemically induced
  • Heart Diseases* / diagnosis
  • Humans
  • Neoplasms / drug therapy*

Substances

  • Antineoplastic Agents