Fc epsilon receptor, a specific differentiation marker transiently expressed on mature B cells before isotype switching

J Exp Med. 1986 Nov 1;164(5):1455-69. doi: 10.1084/jem.164.5.1455.


The expression of Fc epsilon R on human lymphocytes was studied with the anti-Fc epsilon R mAbs. Fc epsilon R was expressed on most mu+,delta+ circulating B cells, whereas T cells did not express Fc epsilon R even in patients with hyper-IgE syndrome. B cells with gamma, alpha, or epsilon phenotype did not express Fc epsilon R, moreover its expression could not be induced, suggesting that the Fc epsilon R expression was correlated with isotype switching. mu+delta+ B cells in bone marrow did not express Fc epsilon R, but PHA-sup (supernatant from PHA-stimulated cell cultures) could induce its expression, and the addition of IgE augmented this induction. Recombinant IL-2, IL-1, IFN-gamma or -beta, or purified B cell differentiation factor (BSF-2 B cell-stimulatory factor 2) could not induce Fc epsilon R expression in bone marrow B cells. IFN-gamma inhibited the Fc epsilon R expression induced by PHA-sup, suggesting that the human counterpart of BSF-1 may be responsible for Fc epsilon R expression in bone marrow B cells. B cells from patients with common variable immunodeficiency and ataxia telangiectasia did not express Fc epsilon R, but PHA-sup could induce its expression, indicating that circulating B cells of these patients are at a differentiation stage similar to B cells in bone marrow. The study showed that Fc epsilon R is a B cell-specific differentiation marker, the expression of which is restricted to a defined stage of B cell differentiation.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • B-Lymphocytes / analysis*
  • B-Lymphocytes / immunology
  • Bone Marrow / analysis
  • Cell Differentiation
  • Humans
  • Immunoglobulin E / immunology
  • Immunoglobulin Isotypes / analysis*
  • Immunologic Deficiency Syndromes / metabolism
  • Lymphokines / pharmacology
  • Palatine Tonsil / analysis
  • Phytohemagglutinins / pharmacology
  • Receptors, Fc / analysis*
  • Receptors, Fc / biosynthesis
  • Receptors, IgE


  • Immunoglobulin Isotypes
  • Lymphokines
  • Phytohemagglutinins
  • Receptors, Fc
  • Receptors, IgE
  • Immunoglobulin E