Anti-hypertensive treatment in peripheral artery disease

Curr Opin Pharmacol. 2018 Apr:39:35-42. doi: 10.1016/j.coph.2018.01.009. Epub 2018 Feb 22.


Peripheral artery disease (PAD) affects more than 200 million people worldwide. Hypertension has been related to increased risk of PAD. The treatment of elevated blood pressure (BP) in these patients is indicated to lower the cardiovascular risk with a BP goal of less than 130/80mmHg. Although there is no evidence that one class of antihypertensive medication or strategy is superior for BP lowering in PAD, the use of renin-angiotensin-system (RAS) inhibitors can be effective to reduce the cardiovascular risk. Beta-blockers (BBs) are not contraindicated. In the presence of carotid atherosclerosis, calcium-channel blockers (CCBs) and angiotensin-converting-enzyme inhibitors are recommended. In fibromuscular dysplasia the treatment of choice is percutaneous renal angioplasty. In renal artery disease optimal medical therapy includes RAS inhibitors, CCBs, BBs and diuretics.

Publication types

  • Review

MeSH terms

  • Adrenergic beta-Antagonists / therapeutic use*
  • Antihypertensive Agents / therapeutic use*
  • Carotid Artery Diseases / drug therapy*
  • Humans
  • Peripheral Arterial Disease / drug therapy*
  • Renal Artery*


  • Adrenergic beta-Antagonists
  • Antihypertensive Agents