Dihydrofolate reductase and membrane translocation: evolution of a classic experiment: Classic landmark papers, irrespective of their age, can teach students how best science is practiced and inspire new experiments

EMBO Rep. 2018 Mar;19(3):e45692. doi: 10.15252/embr.201745692. Epub 2018 Feb 19.


Landmark papers, even if they seem outdated, can still stimulate contemporary research and experiments to address new questions. Here is the tale of a classical experiment that inspired research over three decades.

MeSH terms

  • Education*
  • Evolution, Molecular*
  • Humans
  • Membrane Transport Proteins / genetics
  • Membranes / metabolism
  • Students
  • Tetrahydrofolate Dehydrogenase / genetics*


  • Membrane Transport Proteins
  • Tetrahydrofolate Dehydrogenase