Duodenal Crohn's Disease

Inflamm Bowel Dis. 2018 Feb 15;24(3):546-551. doi: 10.1093/ibd/izx083.


Symptomatic duodenal Crohn's disease (CD) is an uncommon disease presentation, especially in isolation. The most common duodenal disease phenotype is stricturing disease rather than inflammatory or perforating. Most patients are asymptomatic and are therefore diagnosed incidentally by cross-sectional imaging or endoscopy. Medical management includes proton pump inhibitor therapy and immunosuppressive therapy including corticosteroids, immunomodulatory therapy, and biologic therapy. Symptomatic strictures can often be treated medically or endoscopically, and do not always require surgery. Surgical options include resection with primary anastomosis, bypass with a gastrojejunostomy, and strictureplasty. Treatment recommendations are largely based on limited evidence from small series and expert opinion. Therefore, the optimal treatment algorithm remains largely subjective and undefined.

Publication types

  • Review

MeSH terms

  • Crohn Disease / complications*
  • Duodenal Obstruction / diagnosis*
  • Duodenal Obstruction / epidemiology*
  • Duodenal Obstruction / surgery*
  • Endoscopy, Digestive System
  • Humans
  • Prognosis
  • Randomized Controlled Trials as Topic
  • Recurrence
  • Reoperation