Introduction: Septic infection of a lumbar intervertebral disc is a serious disorder which is often difficult to diagnose and appropriately treat because of the rarity of the disease, the varied presentation of symptoms, and the frequency of low-back pain within the overall population. Its etiology can be pyogenic, granulomatous, fungal, or parasitic; its incidence is rising due to increased patient susceptibility and improved diagnostic tools. Conservative treatments involve antibiotics, physical therapy, and/or immobilization. More aggressive management requires discectomy, debridement, and spinal fusion in combination with local and systemic antibiotic administration.
Presentation of cases: Presented here are two case studies of lumbar pyogenic discitis associated with Escherichia coli and Candida albicans infections. Both required single-level anterior discectomy followed by spinal fusion using an antimicrobial silicon nitride (Si3N4) spacer for stabilization without instrumentation. Localized antibiotics were used for only one of the patients. Follow-up CT and MRI scans showed that the infections had been resolved with no recurrence of symptoms.
Discussion: Si3N4 is a relatively new spinal spacer material. It was utilized in these two cases because it reportedly provides a local environment which promotes rapid arthrodesis while resisting bacterial adhesion and biofilm formation. It is also highly compatible with X-ray, MRI, and CT imaging modalities. These properties were particularly attractive for these two cases given the patients' histories, presentation of symptoms, and the decision to forego instrumentation.
Conclusion: The use of Si3N4 as an antimicrobial spacer may lead to improved outcomes for patients with pyogenic discitis of the lumbar spine.
Keywords: Antibacterial; Discitis; Lumbar discectomy and fusion; Silicon nitride.
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