The Effect of Whey Protein Supplementation on the Temporal Recovery of Muscle Function Following Resistance Training: A Systematic Review and Meta-Analysis

Nutrients. 2018 Feb 16;10(2):221. doi: 10.3390/nu10020221.


Whey protein (WP) is a widely consumed nutritional supplement, known to enhance strength and muscle mass during resistance training (RT) regimens. Muscle protein anabolism is acutely elevated following RT, which is further enhanced by WP. As a result, there is reason to suggest that WP supplementation may be an effective nutritional strategy for restoring the acute loss of contractile function that occurs following strenuous RT. This systematic review and meta-analysis provides a synthesis of the literature to date, investigating the effect of WP supplementation on the recovery of contractile function in young, healthy adults. Eight studies, containing 13 randomised control trials (RCTs) were included in this review and meta-analysis, from which individual standardised effect sizes (ESs) were calculated, and a temporal overall ES was determined using a random-effects model. Whilst only half of the individual studies reported beneficial effects for WP, the high-quality evidence taken from the 13 RCTs was meta-analysed, yielding overall positive small to medium effects for WP from < 24 to 96 h (ES range = 0.4 to 0.7), for the temporal restoration of contractile function compared to the control treatment. Whilst the effects for WP were shown to be consistent over time, these results are limited to 13 RCTs, principally supporting the requirement for further comprehensive research in this area.

Keywords: athletic performance; dietary supplements; exercise; humans; recovery of function; resistance training; skeletal muscle; sports; weight lifting; whey proteins.

Publication types

  • Meta-Analysis
  • Review
  • Systematic Review

MeSH terms

  • Dietary Supplements*
  • Female
  • Humans
  • Male
  • Muscle Contraction*
  • Muscle Fatigue
  • Muscle Strength
  • Muscle, Skeletal / metabolism*
  • Recovery of Function
  • Resistance Training*
  • Time Factors
  • Whey Proteins / administration & dosage*
  • Whey Proteins / metabolism


  • Whey Proteins