The beta-endorphin-induced secretion of growth hormone but not of prolactin is inhibited by an endogenous opioid antagonist

Eur J Pharmacol. 1986 Oct 7;129(3):385-7. doi: 10.1016/0014-2999(86)90453-x.

Abstract

The naturally occurring peptide human beta-endorphin-(1-27) (h beta-EP-(1-27) has been shown to antagonize beta-endorphin (h beta-EP)-induced analgesia. We have evaluated the effects of the fragment on h beta-EP-induced growth hormone (GH) and prolactin (PRL) release. It inhibited beta-EP-induced GH release in a dose-related way but left beta-EP-induced PRL stimulation unchanged.

MeSH terms

  • Animals
  • Endorphins / antagonists & inhibitors
  • Endorphins / pharmacology*
  • Growth Hormone / metabolism*
  • Male
  • Peptide Fragments / pharmacology*
  • Prolactin / metabolism*
  • Rats
  • Rats, Inbred Strains
  • beta-Endorphin

Substances

  • Endorphins
  • Peptide Fragments
  • beta-Endorphin
  • beta-endorphin (1-27)
  • Prolactin
  • Growth Hormone