Understanding Subset Diversity in T Cell Memory

Immunity. 2018 Feb 20;48(2):214-226. doi: 10.1016/j.immuni.2018.02.010.


Considerable advances have been made in recent years in understanding the generation and function of memory T cells. Memory T cells are typically parsed into discreet subsets based on phenotypic definitions that connote distinct roles in immunity. Here we consider new developments in the field and focus on how emerging differences between memory cells with respect to their trafficking, metabolism, epigenetic regulation, and longevity may fail to fit into small groups of "memory subsets." Rather, the properties of individual memory T cells fall on a continuum within each of these and other parameters. We discuss how this continuum influences the way that the efficacy of vaccination is assessed, as well as the suitability of a memory population for protective immunity.

Publication types

  • Review

MeSH terms

  • Animals
  • Cell Differentiation
  • Cell Movement
  • Epigenomics
  • Humans
  • Immunologic Memory / immunology*
  • T-Lymphocyte Subsets / cytology
  • T-Lymphocyte Subsets / immunology*
  • T-Lymphocyte Subsets / physiology