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. 2018 Feb 21;18(1):213.
doi: 10.1186/s12885-018-4100-8.

Occurrence of Colorectal Aberrant Crypt Foci Depending on Age and Dietary Patterns of Patients

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Free PMC article

Occurrence of Colorectal Aberrant Crypt Foci Depending on Age and Dietary Patterns of Patients

Marek Kowalczyk et al. BMC Cancer. .
Free PMC article

Abstract

Background: Aberrant crypt foci (ACF) are commonly considered the early pre-cancerous lesions that can progress to colorectal cancer (CRC). The available literature data reveal that age, dietary factors and lifestyle can affect the development of several dozen percentages of malignant tumours, including CRC. In the present study, an attempt was made to assess the incidence and growth dynamics of ACF and to determine whether the type of diet affected the development and number of AFC.

Methods: Colonoscopy combined with rectal mucosa staining with 0.25% methylene blue was performed in 131 patients. On the day of examination, each patient completed a questionnaire regarding epidemiological data. According to their numbers, colorectal ACF were divided into three groups. The findings were analysed statistically. The Student's t test and the U test were applied in order to determine the significance of differences of means and frequency of events in both groups. Statistica 7.1 and Excel 2010 were used.

Results: The single ACF occur in the youngest individuals (ACF < 5). Since the age of 38 years, the number of ACF gradually increases to show a decreasing tendency since the age of 60 years. The number of 5 < ACF < 10 occurs slightly later, since the age of 50 years, and dynamically increases reaching the maximum at the age of 62 years, subsequently the increase is proportional. ACF > 10 occur at a more advanced age (55 years) and their number gradually increases with age. The maximum number is observed at the age of 77 years. In individuals not using high-fibre diets and with high intake of red meat, the probability of higher numbers of ACF increases. The probability of higher numbers of ACF (5 < ACF10) was observed in patients with colon diverticula. In patients with higher BMI, the number of ACF is higher.

Conclusion: Age significantly affects the number of colorectal ACF. The types of foods consumed can considerably increase the risk of colorectal ACF, which is particularly visible in individuals who do not regularly use high-fibre diets, those obese and with colon diverticula.

Keywords: Aberrant crypt foci; Adenoma; Dietary patterns; Large intestine.

Conflict of interest statement

Competing interests

The authors declare that they have no competing interests.

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Figures

Fig. 1
Fig. 1
Age ranges in the study groups
Fig. 2
Fig. 2
Quantification of ACF in various age groups
Fig. 3
Fig. 3
Dynamics of ACF increases in individual age groups
Fig. 4
Fig. 4
Types of ACF in the study group
Fig. 5
Fig. 5
Quantificiation of ACF according to diet
Fig. 6
Fig. 6
Quantificiation of ACF according to diet(continued)
Fig. 7
Fig. 7
Quantification of ACF in patients with colon diverticula
Fig. 8
Fig. 8
Occurrence of ACF according to BMI

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