Different contributions of nonmuscle myosin IIA and IIB to the organization of stress fiber subtypes in fibroblasts

Mol Biol Cell. 2018 Apr 15;29(8):911-922. doi: 10.1091/mbc.E17-04-0215. Epub 2018 Mar 23.


We demonstrated that myosin IIA and IIB are essential for the formation of transverse arcs and ventral stress fibers, respectively. Furthermore, we illustrated the roles of both isoforms in lamellar flattening and also raised the possibility that actin filaments in ventral stress fibers are in a stretched conformation.

Publication types

  • Research Support, Non-U.S. Gov't
  • Video-Audio Media

MeSH terms

  • Cell Line
  • Cell Movement*
  • Cell Polarity
  • Cell Shape
  • Fibroblasts / cytology*
  • Gene Knockdown Techniques
  • Humans
  • Nonmuscle Myosin Type IIA / metabolism*
  • Nonmuscle Myosin Type IIB / metabolism*
  • Phosphorylation
  • Stress Fibers / metabolism*


  • Nonmuscle Myosin Type IIA
  • Nonmuscle Myosin Type IIB