The IDA3 adapter, required for intraflagellar transport of I1 dynein, is regulated by ciliary length

Mol Biol Cell. 2018 Apr 15;29(8):886-896. doi: 10.1091/mbc.E17-12-0729. Epub 2018 Mar 29.

Abstract

We determined how the ciliary motor I1 dynein is transported. A specialized adapter, IDA3, facilitates I1 dynein attachment to the ciliary transporter called intraflagellar transport (IFT). Loading of IDA3 and I1 dynein on IFT is regulated by ciliary length.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Axoneme / metabolism*
  • Chlamydomonas / metabolism*
  • Cilia / metabolism*
  • Dyneins / metabolism*
  • Flagella / metabolism*
  • Kinesin / metabolism
  • Models, Biological
  • Mutation
  • Plant Proteins / metabolism
  • Protein Biosynthesis
  • Protein Transport

Substances

  • Plant Proteins
  • Dyneins
  • Kinesin