Mitochondrial genome variability: the effect on cellular functional activity

Ther Clin Risk Manag. 2018 Feb 9;14:237-245. doi: 10.2147/TCRM.S153895. eCollection 2018.

Abstract

Mitochondria are the key players in cell metabolism, calcium homeostasis, and reactive oxygen species (ROS) production. Mitochondrial genome alterations are reported to be associated with numerous human disorders affecting nearly all tissues. In this review, we discuss the available information on the involvement of mitochondrial DNA (mtDNA) mutations in cell dysfunction.

Keywords: ATP; apoptosis; electron transfer chain; mitochondria; mutation; reactive oxygen species.

Publication types

  • Review