Recent Advances in Hepatotoxicity of Non Steroidal Anti-Inflammatory Drugs

Ann Hepatol. 2018 Mar 1;17(2):187-191. doi: 10.5604/01.3001.0010.8633.


Non-steroidal-anti-inflammatory drugs (NSAIDs) make a heterogenous pharmaco-therapeutic class of drugs among the most used drugs worldwide with various indications, modes of administration and increasing automedication. NSAIDs can cause acute liver injury with variable severity. The recent identification of genetic markers might facilitate the diagnosis and the prediction of hepatotoxicity risk.

Keywords: Drug-induced hepatitis; NSAID; Non-steroidal-anti-inflammatory drugs; hepatotoxicity; pharmacogenetics.

Publication types

  • Review

MeSH terms

  • Animals
  • Anti-Inflammatory Agents, Non-Steroidal / adverse effects*
  • Chemical and Drug Induced Liver Injury / diagnosis
  • Chemical and Drug Induced Liver Injury / epidemiology
  • Chemical and Drug Induced Liver Injury / genetics*
  • Genetic Predisposition to Disease
  • Humans
  • Liver / drug effects*
  • Liver / metabolism
  • Liver / pathology
  • Pharmacogenetics
  • Pharmacogenomic Variants*
  • Phenotype
  • Prognosis
  • Risk Assessment
  • Risk Factors


  • Anti-Inflammatory Agents, Non-Steroidal