Treatment of Hepatitis C during Pregnancy-Weighing the Risks and Benefits in Contrast to HIV

Curr HIV/AIDS Rep. 2018 Apr;15(2):155-161. doi: 10.1007/s11904-018-0386-z.

Abstract

Purpose of review: Increasing hepatitis C virus (HCV) cases over the past decade have raised concerns about subsequent increased cases in infants due to mother to child transmission (MTCT). Many are reminded of the early days of HIV and the rationale for using antiretroviral agents during pregnancy.

Recent findings: Direct-acting antivirals (DAAs) that are highly potent, all-oral, short-duration regimens that cure HCV have led many to consider what it would entail to use DAAs for pregnant women. Considering HIV and Hepatitis B virus (HBV) as two infections with MTCT to draw lessons from, DAA use to interrupt HCV MTCT comes with risks, costs, and many potential benefits. When considering how to effectively curb the current epidemic of HCV in the US population, using DAAs to treat pregnant women with HCV offers potential benefits to the mother immediately, to the pair in the short-term and to the child, family, and society over a lifetime.

Keywords: Hepatitis C; Mother to children transmission; Pregnancy; Vertical transmission.

Publication types

  • Review

MeSH terms

  • Antiviral Agents / therapeutic use
  • Female
  • HIV Infections / complications
  • HIV Infections / drug therapy*
  • HIV Infections / transmission*
  • Hepatitis C / complications
  • Hepatitis C / drug therapy*
  • Hepatitis C / transmission*
  • Humans
  • Infectious Disease Transmission, Vertical / prevention & control*
  • Pregnancy
  • Pregnancy Complications, Infectious / drug therapy*

Substances

  • Antiviral Agents