Interferon Alpha-2a for the Treatment of Post-Infectious Uveitis Secondary to Presumed Intraocular Tuberculosis

Ocul Immunol Inflamm. 2019;27(4):643-650. doi: 10.1080/09273948.2018.1431292. Epub 2018 Feb 22.


Purpose: To assess the efficacy and tolerability of interferon (IFN) alpha-2a in post-infectious uveitis secondary to presumed intraocular tuberculosis (IOTB). Methods: Patients with chronic uveitis secondary to presumed IOTB who, after completing an antitubercular treatment, showed poor response to treatments or recurred after tapering oral corticosteroids to ≤7.5 mg/day were enrolled. All patients were treated with IFN alpha-2a subcutaneous injections. Best-corrected visual acuity (BCVA), central retinal thickness (CRT), and inflammatory signs were compared between baseline and follow-up visits up to six months. Results: Twelve eyes (six patients) were enrolled. Mean BCVA improved from 0.64 ± 0.55 logMAR at baseline to 0.32 ± 0.31 logMAR at 6 months (p = 0.03). Mean CRT decreased from 372 ± 132.2 μm to 274.66 ± 34.9 μm at six months (p = 0.01). Inflammatory signs (vitritis, vasculitis) also decreased overtime. No major complications or tuberculosis reactivations were recorded. Conclusions: IFN alpha-2a was efficacious and safe in treating chronic post-infectious uveitis secondary to presumed IOTB.

Keywords: Infectious; interferon; therapy; tuberculosis; uveitis.

MeSH terms

  • Aged
  • Chronic Disease
  • Dose-Response Relationship, Drug
  • Eye Infections, Bacterial / complications*
  • Eye Infections, Bacterial / diagnosis
  • Female
  • Fluorescein Angiography
  • Follow-Up Studies
  • Fundus Oculi
  • Humans
  • Injections, Subcutaneous
  • Interferon alpha-2 / administration & dosage*
  • Male
  • Middle Aged
  • Retina / pathology
  • Retrospective Studies
  • Tomography, Optical Coherence
  • Treatment Outcome
  • Tuberculosis, Ocular / complications*
  • Tuberculosis, Ocular / diagnosis
  • Uveitis / diagnosis
  • Uveitis / drug therapy*
  • Uveitis / etiology
  • Visual Acuity*


  • Interferon alpha-2